Pharmacy's Laboratory

The Pharmacy's laboratory supports pharmaceutical oncological care through pharmacological research.

The bioanalytical laboratory develops and validates determinations that can support clinical studies such as pharmacokinetics, mass balance, and metabolic profiling studies. Our "Therapeutic Drug Monitoring" (TDM drug overview) service provides physicians with drug levels in the blood and advice to optimize the dose of oral cancer drugs with a narrow therapeutic range. 

The quality control laboratory evaluates active pharmaceutical materials, sem-manufactured goods, and finished products for the laboratory's production department. Methods are developed and validated for this purpose. The quality of all materials used in drug production is tested and all production rooms are checked for environmental and microbiological contaminations. 

Both departments have implemented a quality assurance system. The bioanalytical laboratory can conduct studies in accordance with Good Laboratory Practice legislation (GLP, download GLP certificate) of the ECD and is inspected every 2 years by the government since 1999. The quality assurance laboratory operates in accordance with Good Manufacturing Practice (GMP). An independent quality assurance department (covering all hospital pharmacies) checks whether both laboratories act in accordance with legislation. 


  • Development, validation, and implementation of bioanalytical methods
  • Method transfers
  • Bioanalysis of samples from clinical studies
  • Stability research
  • Therapeutic Drug Monitoring
  • Inspection of active pharmaceutical materials, semi-manufactured goods, and finished products
  • Testing the quality of production materials 
  • Determining environmental and microbiological contaminations

We don't just work for our own hospital but also provide services for third parties. Click here for more information.

Support of clinical trials

  • Toxicology studies
  • Phase 1-4 studies
  • Mass balance and Metabolite Profiling studies
  • Bio-equivalency studies
  • Biological availability studies
  • Food interaction studies
  • Drug interaction studies

TDM service

An overview of all determinations of oral cancer drugs made by the Pharmacy's laboratory for the Therapeutic Drug Monitoring (TDM) can be found at the following link: (TDM information files). These files contain information about the pharmacology of the drug and the materials to be sent in (collection tube, minimal volume, packaging requirements, submission conditions, collection time). Samples can be sent to the Pharmacy's Laboratory together with a fully filled-out form. 

You can find the frequencies of the determinations at the TDM information files. Results will be accompanied by a recommendation by a hospital pharmacist. After analysis, samples will be stored at least two months at a temperature of  -20°C. Then they will be removed.  


Team leader:

    • Hilde Rosing

Study leaders:

    • Matthijs Tibben
    • Luc Lucas
    • Bas Thijssen

Sr. MS operator:

    • Michel Hillebrand


  • Niels de Vries
  • Lianda Nan
  • Dieuwke Meijer
  • Abadi Gebretensae
  • Joke Beukers
  • Nikkie Venekamp
  • Ciska Koopman
  • Joke Schol

Tools and technology

  • Triple quadrupole MS instruments
  • Ion trap and orbitrap MS instruments
  • Induced Couple Plasma MS instrument
  • Liquid Scintillation Counter
  • U(H)PLC technology
  • Conventional HPLC combined with UV, PDA and fluorescent detectors
  • Gas Chromatography
  • Chiral separations (LC and GC)
  • Dried Blood Spots/Mitra analyses
  • Protein Binding
  • Chemical derivatization stechniques
  • Multi-component analyses
  • UV, FT-IR, and NIR spectrophotometers
  • Particle size photometer
  • Optical rotation instrument
  • Melting point instrument
  • density and refractor meter
  • Karl Fisher titrators
  • Disintegration, breaking resistance, and abrasion resistance tester
  • Dissolution tester
  • Endotoxins, sterility, and microbiological contamination tests

Recent publications

Please visit Bioanalytical Laboratory of the Pharmacy under the header 'Recent publications' to find our latest publications.

Contact details

We are open on weekdays between 8:00 and17:00.

Our address:

Antoni van Leeuwenhoek
Pharmacy Laboratory
Plesmanlaan 121
1066 CX Amsterdam

(general) phone number: 020-5129111
Secretariat: 020-5124481

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